Autophagy in Infection and Immunity pdf

Autophagy in Infection and Immunity directory

An Overview of the Molecular Mechanism of Autophagy .......................... 1

Zhifen Yang and Daniel J. Klionsky

Macroautophagy Signaling and Regulation ................................................. 33

Audrey Esclatine, Magali Chaumorcel, and Patrice Codogno

Physiological Functions of Autophagy .......................................................... 71

Noboru Mizushima

Autophagy and Lymphocyte Homeostasis .................................................... 85

Heather H. Pua and You-Wen He

Autophagy and Innate Recognition Systems ................................................ 107

Michal Caspi Tal and Akiko Iwasaki

Autophagy in MHC Class II Presentation of Endogenous Antigens .......... 123

Monique Gannagé and Christian Münz

Role of Autophagy and Autophagy Genes in

Inflammatory Bowel Disease .......................................................................... 141

Ken Cadwell, Thaddeus S. Stappenbeck, and Herbert W. Virgin

Autophagy in Immunity Against Mycobacterium tuberculosis:

a Model System to Dissect Immunological Roles of Autophagy ................. 169

Vojo Deretic, Monica Delgado, Isabelle Vergne, Sharon Master,

Sergio De Haro, Marisa Ponpuak, and Sudha Singh

Autophagy in Immunity Against Intracellular Bacteria ............................. 189

Ju Huang and John H. Brumell

Group A Streptococcus: A Loser in the Battle with Autophagy ................. 217

Tamotsu Yoshimori and Atsuo Amano

Autophagy Subversion by Bacteria ............................................................... 227

Emanuel Campoy and María I. Colombo

Autophagy in Immunity Against Toxoplasma gondii ................................... 251

Carlos S. Subauste

Autophagy in Mammalian Antiviral Immunity ........................................... 267

Anthony Orvedahl and Beth Levine

Something Old, Something New: Plant Innate

Immunity and Autophagy .............................................................................. 287

Montrell Seay, Andrew P. Hayward, Jeffrey Tsao, and S.P. Dinesh-Kumar

Autophagy in HIV-Induced T Cell Death ..................................................... 307

Lucile Espert and Martine Biard-Piechaczyk

Subversion of the Cellular Autophagy Pathway by Viruses ....................... 323

Karla Kirkegaard

Index

Autophagy in Infection and Immunity Wonderful abstract

Abstract Autophagy is a highly conserved cellular degradation process in which portions of cytosol and organelles are sequestered into a double-membrane vesicle,an autophagosome, and delivered into a degradative organelle, the vacuole/lysosome,for breakdown and eventual recycling of the resulting macromolecules. This process relieves the cell from various stress conditions. Autophagy plays a critical role during cellular development and differentiation, functions in tumor suppression, and may be linked to life span extension. Autophagy also has diverse roles in innate and adaptive immunity, such as resistance to pathogen invasion. Substantial progress has been made in the identification of many autophagy-related (ATG) genes that are essential to drive this cellular process, including both selective and nonselective types of autophagy. Identification of the ATG genes in yeast, and the finding of orthologs in other organisms, reveals the conservation of the autophagic machinery in all eukaryotes. Here, we summarize our current knowledge about the machinery and molecular mechanism of autophagy.